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Meng Lv, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang, Xiaodong Mo
《医学前沿(英文)》 2019年 第13卷 第6期 页码 667-679 doi: 10.1007/s11684-019-0702-z
关键词: acute graft-versus-host disease chronic graft-versus-host disease National Institutes of Health consensus criteria acute myeloid leukemia anti-thymocyte globulin
免疫调节细胞生物学及其在急性移植物抗宿主病预防或治疗中的临床应用 Review
Bruce R. Blazar
《工程(英文)》 2019年 第5卷 第1期 页码 98-105 doi: 10.1016/j.eng.2018.11.016
预防和治疗移植物抗宿主病(GVHD)最常见的方法是尝试耗竭或抑制能介导或支持同种异体反应的T细胞;但这会导致T细胞受体功能缺陷,并因此对感染和肿瘤复发高度敏感。通常通过广泛使用反应性抗体来实现耗竭,而功能损坏通常在使用需长期给药(一般为6个月或更长时间)且具有明显副作用的药物后发生,这种药物可能不会导致供体T细胞对耐调节方案且携带宿主同种抗原的细胞产生耐受性(即无反应性)。随着对免疫系统稳态认识的深化,我们已能鉴定和表征具有免疫调节功能的细胞群。虽然这种细胞群通常比较少见,但可通过分离和扩增此类细胞的方法在移植后晚期增补供体移植物或进行输注,来抑制GVHD。本文将探讨GVHD模型中的生物学和临床前概念验证,以及现已发展至临床测试阶段的免疫调节细胞疗法对GVHD的疗效。
关键词: 移植物抗宿主病(GVHD) 免疫调节细胞 细胞疗法
Graft versus host disease after liver transplantation: A case report
Peng-Ji GAO, Xi-Sheng LENG, Dong WANG, Guang-Ming LI, Lei HUANG, Jie GAO, JI-Ye ZHU,
《医学前沿(英文)》 2010年 第4卷 第4期 页码 469-472 doi: 10.1007/s11684-010-0120-8
Meng Lv, Yingjun Chang, Xiaojun Huang
《医学前沿(英文)》 2019年 第13卷 第1期 页码 45-56 doi: 10.1007/s11684-017-0595-7
关键词: haploidentical hematopoietic stem cell transplantation conditioning graft-versus-host disease relapse infection donor selection
Quan LI MD , Weiming LI MD , Ping ZOU MD , Jian ZHANG BM ,
《医学前沿(英文)》 2009年 第3卷 第3期 页码 309-315 doi: 10.1007/s11684-009-0043-4
关键词: graft vs host disease proteinase-activated receptor murine model hematopoietic stem cell transplantation
Molecular pathogenesis of acute myeloid leukemia: A diverse disease with new perspectives
Felicitas THOL, Arnold GANSER
《医学前沿(英文)》 2010年 第4卷 第4期 页码 356-362 doi: 10.1007/s11684-010-0220-5
Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang
《医学前沿(英文)》 2019年 第13卷 第2期 页码 238-249 doi: 10.1007/s11684-017-0599-3
关键词: interferon-α hematopoietic stem cell transplantation minimal residual disease donor lymphocyte infusion
null
《医学前沿(英文)》 2015年 第9卷 第3期 页码 356-360 doi: 10.1007/s11684-015-0404-0
Robotic system has been increasingly used in pancreatectomy. However, the effectiveness of this method remains uncertain. This study compared the surgical outcomes between robot-assisted laparoscopic distal pancreatectomy and conventional laparoscopic distal pancreatectomy. During a 15-year period, 35 patients underwent minimally invasive approach of distal pancreatectomy in our center. Seventeen of these patients had robot-assisted laparoscopic approach, and the remaining 18 had conventional laparoscopic approach. Their operative parameters and perioperative outcomes were analyzed retrospectively in a prospective database. The mean operating time in the robotic group (221.4 min) was significantly longer than that in the laparoscopic group (173.6 min) (P = 0.026). Both robotic and conventional laparoscopic groups presented no significant difference in spleen-preservation rate (52.9% vs. 38.9%) (P = 0.505), operative blood loss (100.3 ml vs. 268.3 ml) (P = 0.29), overall morbidity rate (47.1% vs. 38.9%) (P = 0.73), and post-operative hospital stay (11.4 days vs. 14.2 days) (P = 0.46). Both groups also showed no perioperative mortality. Similar outcomes were observed in robotic distal pancreatectomy and conventional laparoscopic approach. However, robotic approach tended to have the advantages of less blood loss and shorter hospital stay. Further studies are necessary to determine the clinical position of robotic distal pancreatectomy.
关键词: distal pancreatectomy pancreatic neoplasm robotic surgery
Performance and synergistic effect of phenolic and thio antioxidants in ABS graft copolymers
Gongsheng LI, Xuhong GUO, Wang NA, Diancheng HAO, Mingyao ZHANG, Huixuan ZHANG, Jun XU
《化学科学与工程前沿(英文)》 2011年 第5卷 第1期 页码 26-34 doi: 10.1007/s11705-010-0531-8
巨噬细胞在器官移植急性排斥反应中的双重作用 Review
谭亮, 郭易难, 冯畅, 侯仰潇, 谢续标, 赵勇
《工程(英文)》 2022年 第10卷 第3期 页码 21-29 doi: 10.1016/j.eng.2021.10.015
天然免疫细胞在移植免疫反应中发挥着重要作用。巨噬细胞是重要的天然免疫细胞;在发生排斥反应的同种异基因移植器官中,巨噬细胞也是浸润的众多免疫细胞之一。巨噬细胞的浸润与器官移植的短期和长期效果呈负相关。在功能方面,巨噬细胞具有异质性和可塑性。在器官移植排斥反应中,巨噬细胞可以为适应性免疫提呈同种异基因抗原以及提供共刺激信号和细胞因子,也可以直接损伤移植器官。此外,一些具有免疫调节功能的巨噬细胞亚群,可以通过抑制排斥反应和促进免疫耐受来保护移植器官。尽管目前研究人员已认识到巨噬细胞在移植器官损伤过程中的潜在作用,但他们对巨噬细胞在移植排斥反应中的不同作用关注不够。为此,本文就巨噬细胞在急性移植免疫反应中的独特作用以及免疫抑制剂对巨噬细胞的影响进行了综述和讨论。通过分析发现,对于巨噬细胞在移植免疫中的作用的相关研究中,应更多地关注其复杂性和关键功能,并应更多地致力于开发针对巨噬细胞的免疫抑制药物,并使之有利于提高移植器官的长期存活率和移植免疫耐受的建立。
间充质干细胞——新冠病毒肺炎相关急性呼吸窘迫综合征潜在的治疗选择
赵璇, 张毅
《工程(英文)》 2020年 第6卷 第10期 页码 1073-1075 doi: 10.1016/j.eng.2020.05.015
Hong ZHU, Peiyong QIN
《化学科学与工程前沿(英文)》 2011年 第5卷 第3期 页码 330-338 doi: 10.1007/s11705-010-1104-6
关键词:
(-)-epigallocatechin-3-gallate (EGCG)
tea polyphenols
CDA-
《农业科学与工程前沿(英文)》 2023年 第10卷 第3期 页码 374-389 doi: 10.15302/J-FASE-2023501
● NH3 dispersion from a multi-floor pig building was compared to a single-floor building.
关键词: pig building computational fluid dynamics ammonia dispersion
Integrated analysis of gut microbiome and host immune responses in COVID-19
《医学前沿(英文)》 2022年 第16卷 第2期 页码 263-275 doi: 10.1007/s11684-022-0921-6
Clinical characteristics of 19 neonates born to mothers with COVID-19
Wei Liu, Jing Wang, Wenbin Li, Zhaoxian Zhou, Siying Liu, Zhihui Rong
《医学前沿(英文)》 2020年 第14卷 第2期 页码 193-198 doi: 10.1007/s11684-020-0772-y
关键词: coronavirus disease 2019 severe acute respiratory syndrome-associated coronavirus maternal-infant infection newborn
标题 作者 时间 类型 操作
Risk factors for chronic graft-versus-host disease after anti-thymocyte globulin-based haploidenticalhematopoietic stem cell transplantation in acute myeloid leukemia
Meng Lv, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang, Xiaodong Mo
期刊论文
Graft versus host disease after liver transplantation: A case report
Peng-Ji GAO, Xi-Sheng LENG, Dong WANG, Guang-Ming LI, Lei HUANG, Jie GAO, JI-Ye ZHU,
期刊论文
Everyone has a donor: contribution of the Chinese experience to global practice of haploidentical hematopoietic stem cell transplantation
Meng Lv, Yingjun Chang, Xiaojun Huang
期刊论文
Gene and protein expression of proteinase-activated receptor-1, 2 in a murine model of acute graft hostdisease
Quan LI MD , Weiming LI MD , Ping ZOU MD , Jian ZHANG BM ,
期刊论文
Molecular pathogenesis of acute myeloid leukemia: A diverse disease with new perspectives
Felicitas THOL, Arnold GANSER
期刊论文
Interferon-α salvage treatment is effective for patients with acute leukemia/myelodysplastic syndromewith unsatisfactory response to minimal residual disease-directed donor lymphocyte infusion after allogeneic
Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang
期刊论文
Robotic distal pancreatectomy versus conventional laparoscopic distal pancreatectomy: a comparative study
null
期刊论文
Performance and synergistic effect of phenolic and thio antioxidants in ABS graft copolymers
Gongsheng LI, Xuhong GUO, Wang NA, Diancheng HAO, Mingyao ZHANG, Huixuan ZHANG, Jun XU
期刊论文
Separation of epigallocatechin-3-gallate from crude tea polyphenols by using Cellulose diacetate graft
Hong ZHU, Peiyong QIN
期刊论文
AMMONIA DISPERSION FROM MULTI-FLOOR VERSUS STANDARD SINGLE-FLOOR PIG PRODUCTION FACILITIES BASED ON COMPUTATIONAL
期刊论文